Website update in progress!! Click around the website to learn more about current team members and other fun stuff. Or hop over to Instagram to visit the @bunniesofochem account to meet the bunny mascot of Team Sydlik, Doctor Fox (pictures to come ;) )
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The overarching goal of research in the Sydlik group is to develop chemical methods and materials to improve human health. Research projects focus on structure-function relationships in materials at the border of chemistry and engineering. The team employs chemical reactions and the principles of rational design to synthesize smart biomaterials that can use chemistry to program stem cell fate and the properties of the scaffold. This research leverages organic chemistry to synthesize materials that activate pathways to instruct bone regeneration, filling a void at the interface of engineering and medicine. Specifically, we use two platforms materials: functional graphenic materials (FGMs) and polymers. These materials direct the healing process using two complementary pathways: covalent controlled release through labile bonds designed to react with water to release bioactive moieties in vivo, and instructive surfaces with permanent covalent bonds that anchor instructive molecules at the critical biomaterial interface. Specific ongoing projects are as follows:
Cell-instructive Functional Graphenic Materials (FGMs). Such as: Daneshmandi, L; Holt, B. D.; Arnold, A. M.; Laurencin, C.; Sydlik, S. A. “Ultra-low binder content 3D printed calcium phosphate graphene scaffolds as resorbable, osteoinductive matrices that support bone formation in vivo” Sci. Rep., 2022, 12,6960.
Bio-inspired and Bioactive Polymeric Materials. Such as: Wright, Z. M.; Pandit, A.; Holt, B. D.; Sydlik, S. A. “Therapeutic Methacrylic (TMA) comonomers for covalent controlled release from mechanically robust bone cement: Kinetics and structure-function relationships.” Macromolecules
Peptide-based Materials to Treat Drug Overdose. Such as: Eckhart, K. E.; Wood, H.; Taofik, T.; Cao, D. J.; Sydlik, S. A. “Peptide Amphiphiles for drug adsorption: a new approach for drug overdose treatment.” 2023, RSC Applied Polymers, 2, 47- 61.
Heavy Metal Remediation. Such as: Schmidt, S. J.; Dou, W.; Sydlik, S. A “Regeneratable graphene-based water filter to remove heavy metal at home.” 2023, ES&T Water, 3, 2179- 2185.
Sustainable and Degradable FGM-polymer composites. Such as: Vickery, W. M.; Lee, K.; Lee, S. M.; Orlando, J. D.; Sydlik, S. A. “Plastic Composites from Repurposed Polyethylene-Terephthalate Wasted Functionalized Graphene Oxide through Dynamic Depolymerization” ACS Applied Nano Materials, 2024, 7, 3691-3701
Novel Polymer and Functional Graphenic Material Compatibility. Such as: Vickery, W. M.; Wood, H. B.; Orlando, J. D.; Singh, J.; Deng, C.; Zhou, J.-Yi.; Lannie, F.; Porter, A. W.; Sydlik, S. A. “Environmental and health impacts of functional graphenic materials and their ultrasonically altered products” NanoImpact, 2023, 31, 100471.
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| Sydlik Group, Fall 2023 |
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| L to R: Jacob Kadir, Dr. Anne Arnold, Dr. Juhi Singh, Sebastian Guarjardo, Walker Vickery |
And I Want to join the group as MS student
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